Fatty acid esters
Apexbio Technology LLC Solifenacin succinate 242478-38-2 10mM (in 1mL DMSO)
Solifenacin succinate (CAS 242478-38-2) is a selective muscarinic M3 receptor antagonist derived from tetrahydroisoquinoline and quinuclidine It primarily exerts its effect by competitively blocking acetylcholine binding at M3 receptors thereby attenuating muscarinic-mediated intracellular calcium mobilization In receptor binding assays solifenacin displays highest affinity for human M3 receptors (Ki 12 nM) It also selectively inhibits carbachol-induced contractions in isolated rat bladder tissues Consequently solifenacin succinate is frequently employed in biomedical research focused on lower urinary tract physiology and disorders associated with bladder hyperactivity
Apexbio Technology LLC Estradiol valerate 979-32-8 10mM (in 1mL DMSO)
Estradiol valerate is a synthetic estrogen ester and agonist of estrogen receptors (ERs) As a prodrug following administration it undergoes enzymatic hydrolysis to release active estradiol thereby activating estrogen receptor-mediated signaling pathways Estradiol interactions with ER and ER receptors lead to modulation of gene transcription related to cellular growth differentiation reproductive function and endocrine regulation In biomedical research Estradiol valerate frequently serves as a representative estrogenic agent to study ER-mediated biological mechanisms hormone-dependent cellular responses and experimental hormone deficiency models such as menopausal or ovarian dysfunction contexts Common research applications include investigating cellular responses to estrogen stimulation examining reproductive biology mechanisms and evaluating therapeutic strategies targeting hormone receptors
Apexbio Technology LLC Monomethyl auristatin E 474645-27-7 10mM (in 1mL DMSO)
Monomethyl auristatin E (MMAE) is a highly potent antimitotic compound that exerts cytotoxic effects by inhibiting tubulin polymerization Microtubules play essential roles in various cellular processes including intracellular transport cell migration and mitotic chromosome segregation MMAE interrupts this process leading to cell cycle arrest and apoptosis MMAE is commonly utilized in preclinical and clinical studies as the cytotoxic payload in antibody-drug conjugates (ADCs) targeting tumor-specific antigens to selectively deliver cytotoxicity to cancer cells In vitro cell studies and in vivo tumor xenograft models show that antibody conjugation enables specific targeting resulting in reduced off-target toxicity and improved therapeutic index compared to unconjugated cytotoxic agents
Apexbio Technology LLC Monomethyl auristatin E 474645-27-7 1mg
Monomethyl auristatin E (MMAE) is a highly potent antimitotic compound that exerts cytotoxic effects by inhibiting tubulin polymerization Microtubules play essential roles in various cellular processes including intracellular transport cell migration and mitotic chromosome segregation MMAE interrupts this process leading to cell cycle arrest and apoptosis MMAE is commonly utilized in preclinical and clinical studies as the cytotoxic payload in antibody-drug conjugates (ADCs) targeting tumor-specific antigens to selectively deliver cytotoxicity to cancer cells In vitro cell studies and in vivo tumor xenograft models show that antibody conjugation enables specific targeting resulting in reduced off-target toxicity and improved therapeutic index compared to unconjugated cytotoxic agents
Sigma Organic Chemistry (S)-alpha-Amino-gamma-butyrolactone hydrochloride | 1G | 104162 | MFCD00058172 | 0.97
(S)-alpha-Amino-gamma-butyrolactone hydrochloride | 1G | 104162 | MFCD00058172 | 0.97
Sigma Organic Chemistry Fmoc N-hydroxysuccinimide ester | 25G | 82911-69-1 | MFCD00010733 | >=98.0% (HPLC)
Fmoc N-hydroxysuccinimide ester | 25G | 82911-69-1 | MFCD00010733 | >=98.0% (HPLC)
Selleck Chemical LLC Glycerol Tri-n-octanoate
Glycerol Tri-n-octanoate (Glycerol trioctanoate Glycerol tricaprylate Trioctanoin Tricaprylin) is a well-known raw material largely used in cosmetic products
Selleck Chemical LLC Frovatriptan Succinate
Frovatriptan Succinate(SB 209509 Succinate VML 251 Succinate) is the succinate salt form of frovatriptan a synthetic triptan with serotonin (5-HT) receptor agonist activity especially for the 5-HT1B/1D receptors
Selleck Chemical LLC 4-Octyl Itaconate
4-Octyl Itaconate activates Nrf2 signaling to inhibit the production of pro-inflammatory cytokines in human macrophages and systemic lupus erythematosus (SLE) patient-derived PBMCs
Selleck Chemical LLC 4-Octyl Itaconate
4-Octyl Itaconate activates Nrf2 signaling to inhibit the production of pro-inflammatory cytokines in human macrophages and systemic lupus erythematosus (SLE) patient-derived PBMCs
Selleck Chemical LLC Methyl Oleate
Methyl Oleate (oleic acid methyl ester Methyl cis-9-Octadecenoate) is a methyl ester of oleic acid which is a monounsaturated fatty acid and is one of the major components of membrane phospholipids
Selleck Chemical LLC Ethyl acetoacetate
Ethyl acetoacetate found in coffee and coffee products as well as in strawberry and yellow passion fruit juice is a flavouring agent used as a chemical intermediate in the production of a wide variety of compounds
Selleck Chemical LLC Paliperidone Palmitate
Paliperidone Palmitate (9-hydroxyrisperidone palmitate) is a palmitate ester of paliperidone which is a dopamine antagonist and 5-HT2A antagonist of the atypical antipsychotic class
Sigma Aldrich Fine Chemicals Biosciences Methyl 10-undecenoate 96% | 111-81-9 | MFCD00016689 | 25ML
Methyl 10-undecenoate 96% | Purity: 96% | Mol Wt: 198.3 | 111-81-9 | MFCD00016689 | 25ML
Sigma Aldrich Fine Chemicals Biosciences Methyl linolenate >=99% (GC) | 301-00-8 | MFCD00135851 | 1G
Methyl linolenate >=99% (GC) | Purity: >=99% (GC) | Mol Wt: 292.46 | 301-00-8 | MFCD00135851 | 1G